描述

NVP-BHG712是EphB4抑制剂，ED50为25 nM，对c-Raf，c-Src和c-Abl的IC50分别为0.395 μM，1.266 μM和1.667 μM。

相关类别

信号通路 >> 蛋白酪氨酸激酶 >> 艾弗林受体

研究领域 >> 癌症

参考文献

[1]. Martiny-Baron G, et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 2010 Sep;13(3):259-67.

密度

1.4±0.1 g/cm3

分子式

C26H20F3N7O

分子量

503.478

精确质量

503.168152

PSA

101.11000

LogP

4.05

外观性状

white to beige

折射率

1.666

储存条件

?20°C

水溶解性

DMSO: >15mg/mL

符号

GHS06

信号词

Danger

危害声明

H301

警示性声明

P301 + P310

危害码 (欧洲)

T

风险声明 (欧洲)

25

安全声明 (欧洲)

45

危险品运输编码

UN 2811 6.1 / PGIII

EphB4 forward signalling regulates lymphatic valve development.

Nat. Commun. 6 , 6625, (2015)

Bidirectional signalling is regarded as a notable hallmark of the Eph-ephrin signalling system: Eph-dependent forward signalling in Eph-expressing cells and ephrin-dependent reverse signalling in Ephr...

详情

EPHB4 Protein Expression in Vascular Smooth Muscle Cells Regulates Their Contractility, and EPHB4 Deletion Leads to Hypotension in Mice.

J. Biol. Chem. 290 , 14235-44, (2015)

EPH kinases are the largest family of receptor tyrosine kinases, and their ligands, ephrins (EFNs), are also cell surface molecules. This work presents evidence that EPHB4 on vascular smooth muscle ce...

详情

Effect of EPH-ephrin signaling on the growth of human leukemia cells.

Anticancer Res. 34(6) , 2913-8, (2014)

Signaling induced by binding of erythropoietin-producing hepatoma-amplified sequence (EPH) receptors to their cell-surface ephrin ligands is implicated in hematopoiesis and growth of various cancer ce...

详情

NVP-BHG712

4-Methyl-3-{[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-[3-(trifluoromethyl)phenyl]benzamide

4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide