1、产品物理参数：
|
常用名 |
2-[4-[1-(喹啉-6-甲基)-1H-[1,2,3]三唑并[4,5-B]吡嗪-6-基]-1H-吡唑-1-基]乙醇 |
英文名 |
PF-04217903 |
|
CAS号 |
956905-27-4 |
分子量 |
372.383 |
|
密度 |
1.5±0.1 g/cm3 |
沸点 |
718.1±60.0 °C at 760 mmHg |
|
分子式 |
C19H16N8O |
熔点 |
无资料 |
|
闪点 |
388.1±32.9 °C |
|
|
PF-04217903是ATP竞争性c-Met抑制剂，IC50为4.8 nM，对突变型Y1230C无活性。
|
描述 |
PF-04217903是ATP竞争性c-Met抑制剂，IC50为4.8 nM，对突变型Y1230C无活性。 |
|
相关类别 |
信号通路 >> 蛋白酪氨酸激酶 >> c-Met的/HGFR 研究领域 >> 癌症 |
|
参考文献 |
[1]. Timofeevski SL, et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry, 2009, 48(23), 5339-5349. [2]. Shojaei F, et al. HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors. Cancer Res, 2010, 70(24), 10090-10100. [3]. Krumbach R, et al. Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: activation of MET as one mechanism for drug resistance. Eur J Cancer, 2011, 47(8), 1231-1243. |
|
密度 |
1.5±0.1 g/cm3 |
|
沸点 |
718.1±60.0 °C at 760 mmHg |
|
分子式 |
C19H16N8O |
|
分子量 |
372.383 |
|
闪点 |
388.1±32.9 °C |
|
精确质量 |
372.144714 |
|
PSA |
107.43000 |
|
LogP |
0.30 |
|
蒸汽压 |
0.0±2.4 mmHg at 25°C |
|
折射率 |
1.807 |
|
1H-Pyrazole-1-ethanol, 4-[1-(6-quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]- |
|
PF04217903 |
|
PF-04217903 |
