1、产品物理参数：
|
常用名 |
BMS-536924 |
英文名 |
BMS-536924 |
|
CAS号 |
468740-43-4 |
分子量 |
479.959 |
|
密度 |
1.4±0.1 g/cm3 |
沸点 |
无资料 |
|
分子式 |
C25H26ClN5O3 |
熔点 |
无资料 |
|
闪点 |
无资料 |
|
|
BMS-536924是ATP竞争性IGF-1R/IR抑制剂， IC50分别为100 nM/73 nM。
|
描述 |
BMS-536924是ATP竞争性IGF-1R/IR抑制剂， IC50分别为100 nM/73 nM。 |
|
相关类别 |
信号通路 >> 蛋白酪氨酸激酶 >> IGF-1R 信号通路 >> 蛋白酪氨酸激酶 >> 胰岛素受体 研究领域 >> 癌症 |
|
参考文献 |
[1]. Wittman M, et al. Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. J Med Chem. 2005 Sep 8;48(18):5639-43. [2]. Litzenburger BC, et al. BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells. Clin Cancer Res. 2009 Jan 1;15(1):226-37. [3]. Ohashi H, et al. Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers. Cancer Sci. 2012 Feb;103(2):252-61. |
|
密度 |
1.4±0.1 g/cm3 |
|
分子式 |
C25H26ClN5O3 |
|
分子量 |
479.959 |
|
精确质量 |
479.172424 |
|
PSA |
106.27000 |
|
LogP |
2.61 |
|
折射率 |
1.717 |
|
CDK inhibitor |
|
4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one |
|
4-{[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone |
|
CHEMBL401930 |
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4-[[(2S)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO]-3-[7-METHYL-5-(4-MORPHOLINYL)-1H-BENZIMIDAZOL-2-YL]-2(1H)-PYRIDINONE |
|
2(1H)-Pyridinone, 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholinyl)-1H-benzimidazol-2-yl]- |
|
INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR INHIBITOR |
|
BMS-536924 |
