Z-DEVD-FMK, Caspase-3 Inhibitor

Product Information

Material Number: 550378

Size: 1.0 mg

Storage Buffer: Lyophilized in dimethyl sulfoxide (DMSO).

Description

Members of the caspase family play key roles in inflammation and mammalian apoptosis. Z-DEVD-FMK is an irreversible and cell permeable 

inhibitor of caspase-3. The peptide is O-methylated in the P1 position on aspartic acid providing enhanced stability and increased cell 

permeability. This inhibitor can be used to inhibit caspase-3 activity and to study events downsteam of caspase-3 activation. Z-DEVD-FMK 

has a molecular weight of 668 Daltons.

Preparation and Storage

Avoid multiple freeze-thaws of product.

Store the lyophilized Z-DEVD-FMK inhibitor at -20?C. Reconstitute the Z-DEVD-FMK inhibitor in DMSO before use. The 

reconstituted Z-DEVD-FMK inhibitor may be stored in small aliquots at -20?C.

Application Notes

Application

Flow cytometry                Routinely Tested

Suggested Companion Products

Catalog Number   Name                                               Size        Clone

559763              PE Annexin V Apoptosis Detection Kit I 100 tests (none)

Product Notices

 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.